Monthly Archives: July 2020

Plagues and Pandemics: What Can History Teach Us?

We find ourselves in the middle of a pandemic, but how dangerous is Covid-19? Should we stay at home? Do we need to wear masks? We listen to the biologists and politicians debate, and we weigh what they tell us. I think when trying to see the future, though, we must first turn around and look at the past. What cautionary tales does history provide us about plagues and pandemics? Let’s investigate the worst epidemics humans have endured, and maybe we’ll understand why we should take Covid-19 seriously.

I’ve thought and read a great deal about pandemics lately (hmmm, I wonder why?). What did we learn from the great influenza pandemic of 1918, or how did humans respond to the bubonic plague or smallpox?

Over my next three posts, I plan to discuss the worst plagues and pandemics the world has faced. Only one of the deadliest diseases ever to attack humans has been cured. Several of the others can now be treated, but a few infectious diseases remain elusive to us, even today with our advancements in science and medicine.

Let me begin with a plague I’m sure many of you think only belongs in the history books.

Yersinia pestis

The bacterium Yersinia pestis caused three of the deadliest pandemics in recorded history. This organism spawns the bubonic plague, septicemic plague, and pneumonic plague. The bacterium invades but does not harm fleas, and the fleas usually pass it on to small animals such as rats. Humans contract the plague either through flea bites or from exposure to the body fluids of dead animals infected with the bacteria. One to seven days after exposure to Yersinia pestis, a human develops flu-like symptoms, including fever, headaches, and vomiting. In the area where the bacteria entered the skin, painful lymph nodes swell and sometimes even break open. The plague poses a mortality rate of 30-90% if not treated. After the discovery and widespread use of penicillin in the 1940s, the death rate from the plague dropped to 10%.

The following represent three of the worst plague pandemics.

The Plague of Justinian

The Plague of Justinian hit Constantinople, the capital of the Byzantine Empire, in 541 CE. Historians believe the plague crossed the Mediterranean Sea from Egypt, brought by fleas carried on rats hiding in the grain holds of ships. The plague wiped out 40 % of the population of Constantinople and then raced across Europe, Asia, North Africa, and Arabia. In one year, this plague killed an estimated 30 to 50 million people or half the world’s population.

The Black Death

From 1346 to 1353, the Black Death annihilated between 75 to 200 million people in Europe, Africa, and Asia. Between 25% to 60 % of the population of Europe died during this pandemic. Experts believe this outbreak began in Asia and again jumped continents, spread by fleas riding on rats aboard merchant ships. People referred to the plague as the black death because of the black skin spots associated with the disease.

Humans did not know what caused the plague nor how to stop the disease, but they understood it spread by proximity to infected individuals. In Venice, authorities required boats to remain isolated and away from port for forty days to ensure the sailors did not bring the disease to shore. The Italian sailors referred to this forty-day isolation as “quarantino,” from which we derived the word quarantine.

The Great Plague of London

From 1348 to 1665, the plague continued to ravage England. The Great Plague of 1665 was the last and one of the worst of the epidemics, killing 100,000 London residents in six months. The name “Bubonic” derived from the appearance of blackened swellings, or buboes, in the victim’s groin or armpits.

While some reports state that Yersinia pestis is now extinct and no longer a threat, nothing could be further from the truth. In 2007, a wildlife biologist working in the Grand Canyon found a dead mountain lion. Curious about what killed the lion, he performed a necropsy on the animal. A week later, the biologist died. Yersinia pestis had infected both the mountain lion and the biologist. This death was not an isolated incident. Since 2000, the CDC has received between one and 17 reports per year of cases of the plague. Luckily, today we know to treat the plague with antibiotics, and this treatment not only helps stop the spread of the dreaded disease but also usually saves those individuals infected with it. Should Yersinia pestis become resistant to modern-day antibiotics, though, we could again face an epidemic of the plague.

In my next post, I’ll discuss smallpox, cholera, and AIDS. Until then, wear a mask, social distance, and wash your hands. From the Middle Ages to today, doctors have learned those are the only three sure actions humans can take to battle a pandemic.


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Robin Barefield is the author of four Alaska wilderness mystery novels, Big Game, Murder Over Kodiak, and The Fisherman’s Daughter, and Karluk Bones. Also, sign up below to subscribe to her free, monthly newsletter on true murder and mystery in Alaska, and listen to her podcast, Murder and Mystery in the Last Frontier.

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Osmoregulation in Salmon

Osmoregulation is the process of maintaining salt and water balance across the body’s membranes. Any fish faces a challenge to maintain this balance. A freshwater fish struggles to retain salt and not take on too much water, while a saltwater fish tends to lose too much water to the environment and keeps a surplus of salt. Fish have developed behaviors and physiological adaptations to survive in their environments, whether fresh or marine water, but how do fish manage to thrive in both fresh and saltwater?

A catadromous fish spends most of its life in freshwater and then migrates to the ocean to breed. Eels of the genus Anguilla represent catadromous organisms. Anadromous fish begin life in freshwater, spend most of their lives in saltwater, and then return to freshwater to spawn. Pacific salmon and some species of sturgeon are anadromous fish.

How does a salmon maintain the composition of its body fluids within homeostatic limits? How does it reverse its osmoregulation physiology when it swims from a freshwater environment into the ocean or from the ocean to freshwater?

In the ocean, a salmon swims in a fluid nearly three times more concentrated than the composition inside its cells. In such an environment, the fish tends to take on salt from the water and lose water to the denser ocean. This exchange would result in severe dehydration and quickly kill the salmon if the fish did not adequately deal with the issue.

A Salmon faces the opposite problem in freshwater, where it lives in a solution nearly devoid of salts. In this case, the fish has more salt in its body than in its environment, presenting the problem of losing salt to the environment while flooding its body with water.

How does a salmon deal with these two warring issues of osmoregulation? The salmon has evolved behavioral and physiological adaptations to allow it to live in both fresh and saltwater habitats.

In the ocean, a salmon drinks several liters of water a day to maintain its water volume, but in freshwater, it does not drink at all, except for what it takes on during feeding. In freshwater, a salmon’s kidneys produce a large volume of very dilute urine to offset the excess water diffusing into its body fluids. In the ocean environment, though, a salmon’s urine is highly concentrated, consisting mostly of salt ions, and it excretes very little water.

A salmon also has a remarkable adaptation that allows osmoregulation by the fish in both marine and freshwater environments. A salmon uses energy to actively pump Na and Cl ions across the gill epithelial cells against their concentration gradients. In saltwater, the fish pumps NaCl out of its blood and into the surrounding ocean. In freshwater, the pump works in reverse, moving NaCl out of the water, over the gills, and into the blood.

These amazing behavioral and physiological adaptations allow a salmon to move from fresh to saltwater when the fish leaves its nursery area to travel to its ocean feeding grounds and then back from its marine habitat to freshwater when the salmon returns to spawn. The critical changes in osmoregulation are not immediate, though. When a salmon smolt first leaves its home stream, it must rest in brackish water for several days or weeks while it adjusts, and then it will slowly move into water with higher salt concentrations. As the smolt adjusts, its kidneys begin producing more-concentrated urine while the NaCl pumps in its gills reverse direction and start pumping NaCl out of the blood. When the salmon returns to its natal stream to spawn, it must again remain in brackish water for a period while its kidneys adjust, and the NaCl pump changes direction to pump NaCl out of the water and into the blood.

I am always amazed by how animals and plants adjust to the demands of their environment. Anadromous and catadromous fish, however, must adapt to two environments with opposite physiological requirements, and to do this, they flip the switch on osmoregulation from one extreme to the other.


Check out the new and improved Readers and Writers Book Club.

Readers and Writers Book Club Member Benefits Includes:

Save money on books—Fifty Percent Discount.

Access to Author Masterminds author podcasts.

Exclusive, free access to author’s finest short, timely articles.

Participate in the Battle Of The Books.

Participate in monthly book club meetings.

Participate in raffles and prizes.

Participate in Monthly Book Club Discussion with Authors

Receive new and upcoming book club benefits.


Robin Barefield is the author of four Alaska wilderness mystery novels, Big Game, Murder Over Kodiak, and The Fisherman’s Daughter, and Karluk Bones. Also, sign up below to subscribe to her free, monthly newsletter on true murder and mystery in Alaska, and listen to her podcast, Murder and Mystery in the Last Frontier.

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Sign Up for my free, monthly Mystery Newsletter about true crime in Alaska.